Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy
نویسندگان
چکیده
منابع مشابه
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
BACKGROUND Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acid...
متن کاملHypothermia in neonatal hypoxic-ischemic encephalopathy (HIE).
Neonatal hypoxic-ischemic encephalopathy (HIE) significantly affects neurodevelopment in infants and is also considered as an important cause of neonatal deaths worldwide. Medical research is being focused worldwide for the development of therapeutic avenues but it is still managed by supportive care. The latest studies in the above field have shown the efficacy of prolonged cooling of neonate'...
متن کاملEmerging Use of Therapeutic Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy
Objective: Several clinical trials evaluating the efficacy of hypothermia in neonates with encephalopathy have shown significant reduction in death and disability at 18-month follow-up. We sought to: 1) evaluate how the use of hypothermia for neonatal hypoxic ischemic encephalopathy (HIE) is changing in U.S. clinical practice, 2) determine which methods and devices for delivering hypothermia ar...
متن کاملSystemic hypothermia--a "cool" therapy for neonatal hypoxic-ischemic encephalopathy.
Hypoxic–ischemic encephalopathy is an important cause of death and disability in full-term infants. The incidence of moderate or severe hypoxic– ischemic encephalopathy has remained essentially unchanged over the past 20 years, at 1.5 to 2 per 1000 live births in the United States. Approximately 15 to 20 percent of these infants will die, and 20 to 25 percent of those who survive will be disabl...
متن کاملNeonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy.
Neonatal seizures are associated with morbidity and mortality. Hypoxic-ischemic encephalopathy (HIE) is the most common cause of seizures in newborns. Neonatal animal models suggest that therapeutic hypothermia can reduce seizures and epileptiform activity in the setting of hypoxia-ischemia, however data from human studies have conflicting results. In this research highlight, we will discuss th...
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2012
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2011.09.018